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Aazer Nawab on Instagram: "Hypertension causes lacunar infarcts through a chain of structural changes in the deep penetrating arteries of the brain (lenticulostriate arteries, thalamoperforators, pontine perforators). 1)Chronic High BP → Lipohyalinosis •Constant high pressure damages the endothelial lining. •Plasma proteins leak into the vessel wall. •Smooth muscle gets replaced by hyaline material. This process is called lipohyalinosis. Result: the vessel wall becomes thick, weak, and narrowed.
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• Early imaging fndings of ischemic infarct. =Appear within an hour of an AIS. 1. Subtle hypodensity in the lentiform nucleus. 2. Insular ribbon sign (loss of gray-white matter differentiation at the insula). 3. Cortical ribbon sign (loss of gray-white matter differentiation at the cortex). =Imaging fndings are secondary to reduced blood volume and edema. • Other signs. =Hyperdense artery sign. 1. Hyperdense MCA sign (M1 segment); High specifcity (~100%); low sensitivity (17–50%). 2. MCA dot sig
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