Background Exercise systolic blood pressure (SBP) indexed to fitness, expressed as SBP divided by peak metabolic equivalents ...

Objective Gene therapies are increasingly being developed and evaluated to treat complex diseases with multiple genetic causes, including cardiovascular diseases (CVDs). However, these studies have ...

Background Discharge N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a recognised prognostic marker after ...

is an open access journal by BMJ and BCS, publishing original research in cardiovascular medicine. Open Heart considers submissions of a variety of article types, including original research articles, ...

Background Hereditary transthyretin amyloidosis (ATTRv) is a rare multisystem disorder with marked phenotypic heterogeneity.

Cardiovascular disease (CVD) is the most common cause of death in women. Early identification of CVD risk factors in women is often overlooked by physicians leading to delays in diagnosis and ...

Background This study aimed to explore the association of long-term left ventricular assist device (LVAD) support with changes in inflammation and cardiac remodelling in subjects with advanced heart ...

Objective To investigate whether aligning exercise timing with chronotype enhances cardiometabolic and sleep-related benefits in sedentary adults with cardiovascular risk factors. Methods In this ...

Background Japanese guidelines recommend a corticosteroid maintenance dose of 5–10 mg/day for cardiac sarcoidosis (CS); however, the optimal dose remains unclear. This study aimed to evaluate the ...

Background Patients with severe aortic stenosis (AS) are at high risk of mortality, regardless of symptom status. Despite this, aortic valve replacement rates remain low for patients with severe AS ...

Background The role of mineralocorticoid receptor antagonists (MRAs) in acute myocardial infarction (MI) remains controversial, with conflicting evidence from landmark trials. We aimed to assess the ...

Background Coronary artery disease (CAD) is one of the biggest causes of mortality worldwide. Risk stratification for early detection is essential for the primary prevention of CAD. QRISK3 is known to ...