Introduction Osteoporosis and fragility fracture are more frequently found in systemic lupus erythematosus (SLE) patients than in normal population. This study aims to determine the risk factors in ...
Objective To evaluate the safety and durability of telitacicept treatment in patients with SLE by identifying the reasons for treatment discontinuation and potential risk factors for subsequent ...
Objectives To define a clinically meaningful treatment response definition for haemolytic anaemia, that will form part of a novel multidomain outcome measure for SLE clinical trials.Methods An ...
Background Although the increased risk of cardiovascular disease in patients with SLE is well-documented, effective tools for risk stratification remain elusive. This study sought to explore the ...
Objective Biologics for systemic lupus erythematosus (SLE) demonstrate variable treatment responses across trials. We evaluated baseline biomarkers as predictors of response to guide personalised ...
Methods Single-center retrospective case series (Istanbul University-Cerrahpasa; Jan 2019-Aug 2025) of 7 SLE patients (2019 EULAR/ACR) refractory to standard care and RTX, treated with OBZ (1,000 mg ...
Objectives Belimumab (BEL) is a B-cell modulator targeting the central immunopathogenic pathway in SLE by selectively inhibiting B lymphocyte stimulator and reducing autoreactive B cells that drive ...
Objectives Cutaneous manifestations of lupus are common, yet effective therapies targeting the underlying pathogenesis are lacking. Toll-like receptors (TLR) 7/8 are key upstream drivers of the ...
Objectives In patients with SLE treated with ANI in clinical practice in Spain, our aim was to assess a) the profile of patients receiving ANI b) effectiveness and c) safety. Methods Observational ...
Proteomic analysis reveals angiogenesis-related plasma proteins associated with pre-eclampsia in SLE
Objective Delivery of a small for gestational age (SGA) infant is a common pregnancy complication among women with SLE. Although disease activity and autoantibodies such as anti-Smith and ...
Objectives This study examined if lowering the glucocorticoid (GC) ceiling in the definition of lupus low disease activity state (LLDAS) from 7.5 mg/day to 5 mg/day (LLDAS-5) was associated with ...
Objectives Neuropsychiatric SLE (NPSLE) lacks evidence-based treatment strategies. This study compared the effectiveness and safety profiles of obinutuzumab (OBZ) and rituximab (RTX) in patients with ...
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