The number of injuries the 49ers have had to deal with so far this season is almost mind-boggling. On offense, quarterback Brock Purdy has only played in two games, while several of the team’s key playmakers, such as Kittle, Brandon Aiyuk, Jauan Jennings, and Ricky Pearsall, have all missed time with their own injuries.

He’s on pace to finish the season with 1,129 rushing yards and seven scores and 129 catches for 1,253 yards and seven touchdowns. He leads the NFL with 132 carries, rushing for 435 yards and three scores and has 53 catches for 516 yards and three touchdowns.

The San Francisco 49ers have been contenders for several years, and defensive coordinator Robert Saleh revealed one of the keys to that success.

Quarterback Brock Purdy will miss his fourth straight game and sixth in the past seven weeks for the San Francisco 49ers with a toe injury. Coach Kyle Shanahan said Friday (Saturday in Manila) that Purdy was ruled out this week against the Houston Texans but will travel for the game as his condition has improved.

Niners quarterback Brock Purdy has been ruled out for Sunday's game against the Texans, head coach Kyle Shanahan said. Mac Jones is set to start once again.