No. 1 seed Duke vs. No. 1 seed Houston has the makings of a March Madness classic (in April) at the Alamodome in San Antonio, Texas.

One of these No. 1 seeds is not like the other. Sports betting books list Duke as a clear favorite in the men's Final Four, but hang on just a second.

Take a look at the site's Final Four picks for the NCAA Tournament semifinal matchups, which start with the Florida Gators vs Auburn Tigers and conclude with the Duke Blue Devils vs Houston ...

Final Four picks, predictions, odds explain why Houston Cougars will beat Duke Blue Devils in NCAA Tournament March Madness game Saturday, April 5.

Madness picks, predictions, odds for Houston Cougars vs Duke Blue Devils NCAA Tournament bracket men's Final Four game Saturday, April 5, 2025.

Final Four picks, predictions, odds for Duke Blue Devils vs Houston Cougars NCAA Tournament March Madness game Saturday, April 5, 2025. Who wins game?

The SportsLine Projection Model has revealed its picks for Cooper Flagg and the Duke Blue Devils vs. the Houston Cougars in ...

Madness is almost over, but three big games remain. Here are our Duke vs. Houston predictions, picks and best bets for the ...

Proctor has spent all three years of his college career with the Blue Devils, developing into a deadly long-range shooter. He ...

One of those games is the Houston Cougars taking on the Duke Blue Devils in a showdown between two top programs in college ...

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Final Four picks, predictions, odds explain why Duke Blue Devils will beat Houston Cougars in NCAA Tournament March Madness game Saturday, April 5.