by Dr. Bart Loeys of Howard Hughes Medical Institutes and Johns Hopkins University in Baltimore, and colleagues was titled, "Mutations in Fibrillin-1 Cause Congenital Scleroderma: Stiff Skin ...

Scleroderma is a rare disease in which a person's immune system begins to destroy normal ... This change causes the tissues to become stiff and the muscles to not work as well. In the esophagus, this ...