Fluorogenic DNA aptamers produce light only in the correct structural state, enabling programmable molecular logic, ...

We have long struggled to determine how the first living organisms on Earth came together. Now, surprising evidence hints that poorly understood prions may have been the vital missing ingredient ...

Protego Biopharma is advancing a small-molecule drug that helps light chain proteins fold correctly, in turn addressing the underlying biological cause of AL amyloidosis.

DNA scaffolds that mirror influenza virus protein geometry boost antiviral binding and reduce infection more effectively than free molecules, enabling a modular antiviral design strategy.

In five years since AlphaFold's debut, it has transformed basic biochemical research. But its long-term effect on drug ...

Researchers have discovered how the GRP94 protein enlists the help of other proteins to shield it from glycosylation.

Around 80% of proteins involved in diseases like cancer and neurodegenerative illnesses do not have a stable structure. These proteins, known as intrinsically disordered proteins (IDPs) can quickly ...

Around 80 percent of proteins involved in diseases like cancer and neurodegenerative illnesses do not have a stable structure. These proteins, known ...

A new AI model is opening the black box of the leading artificial intelligence tool for predicting how proteins will interact with small molecules, such as drugs. The model, OpenFold3, which launched ...

Fully open source model accurately predicts the 3D structures of proteins and biomolecules in silico, and serves as a foundational model for next generation of cutting-edge Protein AI tools The ...

Randal Halfmann at the Stowers Institute for Medical Research in Kansas City is hoping to treat diseases including cancer and Alzheimer's by influencing how cells make life-or-death decisions. In ...

Scientists are hoping to treat diseases including cancer and Alzheimer's by influencing how cells make life-or-death decisions. In Alzheimer's, brain cells die too soon. In cancer, dangerous cells don ...