Granuloma formation within media. CD4 + T cells secrete IFN-γ and TNF-α which together are responsible for recruitment of macrophages. ... Giant cell arteritis (GCA) ...

In giant cell arteritis, immune cells react against blood vessels and make them inflamed. Doctors don't know what triggers this, but you're more likely to get it if you're: Over 50; ...

“While the phase 3 results of GCAptAIN did not replicate the positive outcomes observed in the phase 2 trial, we remain committed to continuing to drive scientific progress and deepening the ...

SHREVEPORT, La. - Giant cell arteritis, also known as temporal arteritis, is a less common condition where people get inflammation of the arteries that go to the head and neck.

Upadacitinib 15 mg — but not 7.5 mg — alongside a glucocorticoid taper demonstrated superior efficacy to placebo with a ...

Causes of Giant Cell Arteritis (Temporal Arteritis):Giant Cell Arteritis is an autoimmune disorder where the immune system mistakenly attacks healthy blood vessels, leading to inflammation. While ...

A common medication already used for autoimmune diseases such as rheumatoid arthritis is effective for patients with giant ...

Patients with giant cell arteritis treated daily with prednisone were randomized to one of three different groups: the control group that received placebo medications; a group that received 7.5 ...

The Food and Drug Administration (FDA) has approved Rinvoq ® (upadacitinib), a Janus kinase (JAK) inhibitor, for the treatment of adults with giant cell arteritis (GCA).. The approval was based ...

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Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are linked conditions that occur in the elderly. GCA is a vasculitis of large- and medium-sized vessels causing critical ischemia.