Granuloma Formation to Neutralize Antigen Mature and activated DCs present antigen to CD4 + T cells in the adventitia, leading to T-cell activation and proliferation.

Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are linked conditions that occur in the elderly. GCA is a vasculitis of large- and medium-sized vessels causing critical ischemia.

“While the phase 3 results of GCAptAIN did not replicate the positive outcomes observed in the phase 2 trial, we remain committed to continuing to drive scientific progress and deepening the ...

A common medication already used for autoimmune diseases such as rheumatoid arthritis is effective for patients with giant ...

Cosentyx missed its main goal in a Phase 3 GCA study, but showed lower steroid use. Novartis plans full review of the trial ...

Upadacitinib 15 mg — but not 7.5 mg — alongside a glucocorticoid taper demonstrated superior efficacy to placebo with a ...

Novartis (NVS) stock slips as the company's anti-inflammatory agent Cosentyx fails primary goal in a Phase 3 trial for giant ...

Giant cell granuloma and its related lesions constitute a diverse group of benign yet potentially aggressive osseous entities that primarily affect the craniofacial region.

Peripheral giant cell granuloma (PGCG) is a benign, reactive oral lesion that predominantly affects the gingival and alveolar mucosa. Clinically, PGCG manifests as a red to purple exophytic mass ...

Novartis NVS announced that a late-stage study of its interleukin-17A inhibitor, Cosentyx (secukinumab), has failed to meet ...

A Kristoff St. John documentary from Fallen Giant Films is in the works for release next year, Deadline has learned.

In total, 150 adults with rheumatoid arthritis (RA), axial spondyloarthritis (axSpA), or giant cell arteritis (GCA) who had an indication to receive RZV were prospectively included.