The 2025 men's NCAA tournament began with 68 teams looking to raise a banner and write their name into college basketball history. The Auburn Tigers, the overall No. 1 seed in the South, are looking to avenge their SEC tournament loss and claim the title as the best team in the country,

The Houston Cougars pulled off a shocking upset Saturday evening, beating the Duke Blue Devils 70-67 outright as 4.5-point underdogs. Houston ended the game on a 9-0 run and was down as many as 14 points in the second half. Earlier in the day, the Florida Gators (-2.5) beat the Auburn Tigers 79-73, led by 34 points from Walter Clayton Jr.

What are Final Four odds now? What to know about Houston Cougars vs Duke Blue Devils point spread, moneyline, over/under for March Madness betting.