We solved the structure of PDK1 complexed with ATP and a low-molecular-weight compound termed PS48 , obtained from a crystal soaked with PS48, to 1.9-Å resolution (R-factor 0.17; R free 0.18 ...

Nimbus Therapeutics Publishes First-Ever High-Resolution Structure of ATP-Citrate Lyase. Research published in Nature utilizes cryo-EM to determine structure of critical metabolic protein.

A simple two-carbon compound may have been a crucial player in the evolution of metabolism ... But building ATP's complex chemical structure from scratch is energy intensive and requires six ...

How it works. ATP works by losing the endmost phosphate group when instructed to do so by an enzyme. This reaction releases a lot of energy, which the organism can then use to build proteins, contact ...

Even though scientists have known its roles and structure for years, exactly how it functions has been unclear. Ueda and his team crystalized the ABCB1 protein before and after it exported a compound.

Suk Ahn found that like most kinase inhibitors, two of the compounds competed with ATP for binding to Cdk5. Structural analysis of crystals formed upon incubating the inhibitors with Cdk5 and p25 also ...