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Novel compound attacks tuberculosis bacteria's ATP synthase, showing promise against drug resistance
Researchers at Martin Luther University Halle-Wittenberg (MLU) have developed a promising new substance for targeting ...
Researchers at Martin Luther University Halle-Wittenberg (MLU) have developed a promising new substance for targeting ...
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Nimbus Therapeutics, a biotechnology company applying deep computational expertise throughout drug discovery and development, today published research in Nature ...
The chemical ATP, adenosine triphosphate, is the fuel that powers all life. Despite ATP's central role, the structure of the enzyme generating ATP, F1Fo-ATP synthase, in mammals, including humans, has ...
ATP synthase is a universal molecular machine for energy conversion. By coupling to cellular respiration in mitochondria, it catalyzes conversion of chemical energy of cells. Mitochondrial ATP ...
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Researchers decode tertiary structure of DNA aptamer–ATP complex and improve binding affinity
DNA aptamers are powerful molecular tools in biosensing, bioimaging and therapeutics. However, a limited understanding of their tertiary structures and binding mechanisms hinders their further ...
The link between p38 mitogen-activated protein (MAP) kinase (p38) and many diseases has led to an avalanche of research dedicated to finding inhibitors of this signal-transduction molecule. In Nature ...
iCeMS scientists have revealed how a transporter protein twists and squeezes compounds out of cells, including chemotherapy drugs from some cancer cells In 1986, cellular biochemist Kazumitsu Ueda, ...
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