In five years since AlphaFold's debut, it has transformed basic biochemical research. But its long-term effect on drug ...

Proteins are often called the building blocks of cells, but even those building blocks need to be built. One of the most ...

Protego Biopharma is advancing a small-molecule drug that helps light chain proteins fold correctly, in turn addressing the underlying biological cause of AL amyloidosis.

Researchers have discovered how the GRP94 protein enlists the help of other proteins to shield it from glycosylation.

Around 80% of proteins involved in diseases like cancer and neurodegenerative illnesses do not have a stable structure. These proteins, known as intrinsically disordered proteins (IDPs) can quickly ...

We have long struggled to determine how the first living organisms on Earth came together. Now, surprising evidence hints that poorly understood prions may have been the vital missing ingredient ...

Proteins are often called the building blocks of cells, but even those building blocks need to be built. One of the most important steps in the ...

Multifunctional proteinThe study focused on a folded segment known as the cold-shock domain (CSD/CSDex) within the YB1 protein, an IDP with multiple ...

A Johns Hopkins Medicine study involving a dozen people with the inflammatory skin disease hidradenitis suppurativa (HS), ...

This study investigates the folding and unfolding behavior of the doubly knotted protein TrmD-Tm1570, providing insight into the molecular mechanisms underlying protein knotting. The findings reveal ...

Proteins are often called the building blocks of cells, but even those building blocks need to be built. One of the most important steps in the process of building proteins is glycosylation, when ...