So what is creatine, anyway? Creatine is a naturally occurring substance that provides energy. Your body—specifically your liver, kidneys, and pancreas—produces it from three amino acids, a.k ...

KRAS-targeted therapies, including daraxonrasib and zoldonrasib, show promise in overcoming resistance in cancer treatment, as highlighted at the 2025 meeting of the American Association for ...

Quantum computing and artificial intelligence (AI) can be combined with classical computing methods to design and discover small-molecule candidates that target the cancer-driving KRAS protein ...

It is approved for NSCLC treatment in adults with the KRAS G12C mutation who have received a minimum of one systemic therapy. Dupert is orally administered and targets the guanosine ...

Abbreviations: TCA- Tricarboxylic acid cycle, PPP- Pentose Phosphate Pathway, dNTPs-deoxy Nucleoside Triphosphates, Qp-cell specific productivity, AMP- Adenosine monophosphate, GMP- Guanosine ...

Ribavarin inhibited the FVSKG2 replication in chicken embryo fibroblasts primarily through IMPDH-mediated depletion of the Guanosine Triphosphate pool of cells.

Demonstration of a guanosine triphosphate-dependent enzymatic binding of aminoacyl-ribonucleic acid to Escherichia coli ribosomes.

For the biochemically uninitiated, GEF is guanine nucleotide exchange factor; Sec7 is a domain responsible for some GEF catalytic activity; and Arf1p is a hydrolase enzyme that binds to the nucleotide ...

We now know that KRAS is a plasma membrane–bound protein 21 and a member of a large family of hundreds of different proteins known as GTPases, enzymes that bind to the nucleotide guanosine ...

GTP=guanosine triphosphate; R=receptor Fig. 2 The three mechanisms of vasodilatation. cAMP=3’,5’-cyclic adenosine monophosphate; cGMP=cyclic guanosine monophosphate; EDRFs=endothelium-derived relaxing ...