G proteins often play the role of initial molecular switch in this cascade. The switch is `on' when guanosine triphosphate (GTP) is bound to the G proteins, and `off' when guanosine diphosphate (GDP) ...

According to this model, mutant KRAS is able to hydrolyze guanosine triphosphate (GTP) and cycle between its active (GTP-bound) and inactive (guanosine diphosphate [GDP]–bound) states ...

Quantum computing and artificial intelligence (AI) can be combined with classical computing methods to design and discover small-molecule candidates that target the cancer-driving KRAS protein, ...

Yulan Xiong, associate professor of neuroscience at UConn Health, and her team have discovered one more piece of the puzzle ...

Yulan Xiong and her team have discovered a much-searched-for regulator that plays a key role in genetic causes of Parkinson's ...

GTPase: A type of enzyme that hydrolyzes guanosine triphosphate (GTP) to guanosine diphosphate (GDP), playing a crucial role in cellular signaling. This Nature Research Intelligence Topic summary ...

GTPase: A family of enzymes that hydrolyze guanosine triphosphate (GTP) and are involved in various cellular processes, including signal transduction and protein synthesis. Autophagy: A cellular ...

See text for details. Nitric oxide (NO); ryanodine receptor (RyR); guanylate cyclase (GC); guanosine triphosphate (GTP); cyclic guanosine monophosphate (cGMP); sarco/endoplasmic reticulum calcium ...