Patients with lupus nephritis receiving obinutuzumab plus standard therapy demonstrated high rates of complete histologic remission.

Acute kidney injury (AKI) is a common and serious disease entity that affects native kidneys and allografts but for which no specific treatments exist. Complex intrarenal inflammatory processes driven ...

University of Florence–led investigators report that estrogen-regulated renal progenitor cells shape pregnancy adaptation in mice with failure of estrogen receptor alpha signaling precipitating ...

The U.S. Food and Drug Administration has approved Merck's Welireg (belzutifan) in combination with pembrolizumab or ...

Acute kidney injury (AKI) and chronic kidney disease (CKD) are inter-related clinical and pathophysiological disorders. Cells of the innate immune system, such as granulocytes and macrophages, can ...

Natural killer cells, also referred to as NK cells, play several major roles in the body's defense against cancers like renal cell carcinoma. Natural killer cells, also referred to as NK cells, play ...

aProximate TM is an advanced in vitro model of kidney proximal tubule cells (PTCs) that closely mimics physiological conditions. Derived from fresh human kidney tissue, aProximate TM PTCs are cultured ...

A group of essential signaling molecules known as the Wnt pathway emerged early in the evolution of multicellular life. Scientists have been studying Wnt actions for four decades to comprehend its ...

Chronic kidney disease (CKD) affects more than 10% of the global population and is expected to become the fifth leading cause of death worldwide within the next two decades. Perhaps surprisingly, ...

CD45 + C1q + CCR8+ cells may serve as a biomarker for kidney disease severity and progression risk, reflecting inflammation and fibrosis. Elevated levels of these cells correlate with serum creatinine ...

Mayo Clinic researchers have identified a previously unrecognized way the kidneys regulate water balance - an advance that ...