Purpose: Interferon regulatory factor 6 encodes a member of the IRF family of transcription factors. Mutations in interferon regulatory factor 6 cause Van der Woude and popliteal pterygium syndrome, ...

Alyssia Crook, now 15 and in Rochester this week for the National Junior Disability Championships, has a rare genetic disease called popliteal pterygium syndrome. It affects fewer than 1 in 10,000 ...

IRF6 (Interferon regulatory factor-6)-related disorders are a group of orofacial clefting conditions, including Van der Woude syndrome (VWS) and popliteal pterygium syndrome (PPS). VWS and PPS ...

Multiple pterygium syndrome is a relatively rare disorder characterized by pterygia of the neck, axilla, digits, antecubital, popliteal and intercrural areas. Affected individuals may also have ...