Cytochrome P450 enzymes constitute a vast and diverse superfamily of haem‐containing proteins that orchestrate a broad array of oxidative reactions. Their inherent versatility enables them to catalyse ...

A new in vivo pharmacokinetic recall study involving 114 participants in the Estonian Biobank has provided the first clinical ...

Study reveals an important discovery in the realm of nanomachines within living systems. Prof. Sason Shaik from the Hebrew University of Jerusalem and Dr. Kshatresh Dutta Dubey from Shiv Nadar ...

Cytochrome P450 enzymes constitute a superfamily of haem-containing proteins that catalyse the oxidation of a wide range of exogenous and endogenous compounds. Their function is fundamental to the ...

A new study suggests that Cytochromes P450 (CYP450s) enzymes can sense and respond to stimuli, acting like soft robots in living systems. Study reveals an important discovery in the realm of ...

Editor’s note: This week’s Deep Dive feature focuses on human enzyme research. RESEARCH TRIANGLE PARK – It’s the biggest National Institutes of Health grant in Appalachian State University’s history, ...

Tamoxifen reduces the rate of breast cancer recurrence by approximately a half. Tamoxifen is metabolized to more active metabolites by enzymes encoded by polymorphic genes, including cytochrome P450 ...

Structure of a twisting BINOL radical shown with a P450 enzyme in the background. A BINOL radical twists within a P450 enzyme. Credit: S. Luke Schulert Students of stereochemistry know that chirality ...

M. Ekroos and T. Sjögren, "Structural basis for ligand promiscuity in cytochrome P450 3A4," Proc Natl Acad Sci, 103:13682-7, 2006. (Cited in 78 papers) Researchers at AstraZeneca in MöIndal, Sweden, ...

Using directed evolution, scientists have created the first enzyme known to break a silicon-carbon bond. The finding could be a preliminary step toward biodegrading volatile methyl siloxanes—chemicals ...