In this Healio Video Perspective from Hawaiian Eye 2025, Riad Sherif, MD, CEO of Oculis, discusses data on OCS-05 for the ...

Optic neuritis (ON) is an inflammation that damages your optic nerve. It can cause vision loss and pain when you move your eyes. As the inflammation goes away, your symptoms usually get better.

The RNFL comprises of unmyelinated axons originating from the retinal ganglion cell bodies. During acute optic neuritis onset, RNFL thickness first increases due to optic nerve swelling during ...

The most commonly reported ocular features of infection include: linearly arranged or scattered chorioretinal lesions, anterior uveitis, retinal vasculitis, optic neuritis and vitritis.

Secondary endpoints evaluated changes in retinal structure using optical ... "Oculis’ acute optic neuritis therapy trial meets primary endpoint" was originally created and published by Clinical ...

Naismith et al. state that they preferentially recruited patients with severe optic neuritis (with ≤20/200 vision) and poor recovery (to <20/40 vision).This bias in selecting study participants ...

protecting retinal ganglion cells and the axons, and its ability to improve visual function in patients suffering from acute optic neuritis.” The phase 2 ACUITY trial met primary and secondary ...

and the consistent improvement in retinal structure highlights the therapeutic potential of OCS-05 across multiple ophthalmic and neurological conditions. We are excited to further advance OCS-05’s ...

Other features include anterior uveitis, retinal vasculitis, optic neuritis and vitritis; less commonly, nystagmus, abducens nerve palsy, optic disc edema and absence of corneal reflex have been ...