If neurons are wires, myelin is the insulation that wraps around them; without it, current loss occurs and the circuit weakens. This is analogous to what happens in demyelinating diseases such as ...

Oligodendrocytes, the myelinating cells of the central nervous system (CNS), play a crucial role in myelin generation, maintenance, and repair after CNS injuries and in demyelinating diseases. Beyond ...

In a lab study, a combo of anti-aging drugs appeared to cause a profound loss of the protective coating myelin, which is a ...

New research may help scientists locate immature cells in the central nervous system that could shed light on the causes of neurodegenerative diseases like multiple sclerosis - and autoimmune disease ...

Oligodendrocytes are an important source of amyloid beta (Aβ) and play a key role in promoting neuronal dysfunction in Alzheimer's disease (AD), according to a study published July 23, 2024 in the ...

Researchers from Institute of Genetics and Developmental Biology of Chinese Academy of Sciences generated mice with conditional knockout (cKO) of Mea6 in oligodendrocytes. Using different models of ...

The results of preclinical studies headed by investigators at the UK Dementia Research Institute at University College London, and colleagues, suggest that non-neuronal brain cells called ...

The loss of myelin in the cerebral cortex of multiple sclerosis (MS) patients could be recovered if oligodendrocytes, the cells that myelinate neuronal axons, work at a higher rate than they are ...

Micro RNAs (miRNAs) are short non-coding RNAs that regulate gene expression at posttranscriptional level by complementary binding to 3’UTR regions of target genes. Modulation of gene expression by ...

More than half amount in adult human brain is made up of white matter. Lipid-rich myelin is a special structure formed by oligodendrocytes wrapping neuronal axons to form the major components of white ...

Transplanted human glial cells could outcompete human glia in a chimeric mouse model of Huntington’s disease, inducing apoptosis. And younger health cells could outcompete older ones. The findings, ...