DNA methyltransferase 1 (DNMT1) is an important DNA methyltransferase that maintains DNA methylation. The retention of DNMT1 and its cofactor UHRF1 in the cytoplasm is considered a major reason for ...
In a JNeurosci paper, Tian-Ming Gao and colleagues, from Southern Medical University, explored how adenosine triphosphate (ATP) signaling relates to depression and anxiety using male mice. ATP is a ...
Autism is difficult to study and more difficult to treat because it is an individual condition lacking precise quantification. The development of mouse models of human mental disorders has proven a ...
Retinitis pigmentosa retinal degeneration is caused by a family of hereditary mutations in nearly 100 genes that slowly lead to blindness over years or decades. One of those genes encodes the enzyme ...
A remote fear memory is a memory of traumatic events that occurred in the distant past - a few months to decades ago. A University of California, Riverside, mouse study published in Nature ...
Mouse models of colorectal cancer have been instrumental in elucidating the genetic and cellular pathways that drive tumour initiation, progression and metastasis. Chemically induced systems, using ...
Bacterial translocation refers to the movement of microbes or their products from the gut lumen across the mucosal barrier into sterile tissues or the circulation. Gnotobiotic mouse models—mice raised ...
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