To improve the treatment of patients with metastatic cancer, responsible for 67%-90% of all cancer-related deaths, there is an “urgent” need to abandon the classification of tumors by organ of origin, such as colon, breast, or pancreas, in favor of one ...

Researchers from the University of Notre Dame have published the first known detailed study of breast cancer tissue from Native American women. The study, published in npj Precision Oncology, reveals important molecular differences that may impact the efficacy of therapies for female,

Purinergic signaling, mediated by extracellular nucleotides such as ATP and UTP, has been increasingly studied for its role in regulating cellular communication. A new review by researchers in Singapore examines the P2Y2 receptor, a G protein–coupled ...

Molecular glues are small, monovalent molecules that reshape an E3 ubiquitin ligase (E3) surface to promote a new protein-protein interaction with a target, triggering ubiquitination and removal by the ubiquitin-proteasome system (UPS). In contrast ...

For decades, the molecular switch that drives most pancreatic cancers was ‘undruggable’. No longer. A new drug has now nearly doubled how long patients live.

Postdoctoral researcher Urmila Sehrawat discusses her work at Memorial Sloan Kettering Cancer Center on translational machinery and novel cancer therapeutics.

University of Virginia School of Medicine scientists have revealed how mistakes in the final step of cell division can have dire consequences for developing brain cells. The findings offer important new insights into cancer and developmental disorders,