Spatial biology technologies are reshaping modern biomedical research by enabling the visualization of cellular organization ...

Never-before-seen 3D reconstructions of human liver tissue have been created at a cellular level. The details obtained by a team of UW Medicine and University of Washington engineers and physicians ...

Microscopy is an indispensable tool for collecting biomedical information in pathological diagnosis, but manual annotation, measurement and interpretation are labor-intensive and costly. Here, we ...

The genetic “BOOST” strategy integrates tissue engineering and synthetic biology tools to enable on-demand liver growth inside the body. By specifically rewiring the gene expression of primary liver ...

Although liver biopsy is a well-established technique to assess fibrosis it has several limitations, including invasive nature, semi-quantitative assessment methods, significant sampling and observer ...

The liver has a unique structure, especially at the level of individual cells. Hepatocytes, the main liver cells, release bile into tiny channels called bile canaliculi, which drain into the bile duct ...

More than 100 million people in the United States suffer from metabolic dysfunction-associated steatotic liver disease (MASLD), characterized by a buildup of fat in the liver. This condition can lead ...

Because of the simple laws of supply and demand, many people every year die waiting for an organ that might’ve saved their life. While advanced perfusion and xenotransplantation breakthroughs could ...

Close-up of a human liver lobule highlighting GLUL (glutamine synthetase) + liver cells surrounding the central vein (grey), with intensity-based pseudocoloring of CD32b expression showing the highest ...