The term “bronze diabetes” might sound like it belongs in a history book, but it is actually a very descriptive term for a ...

Expert Rev Mol Diagn. 2010;10(6):755-763. The diagnosis is based on a three-step strategy. The first step is recognizing clinical signs and symptoms. Many symptoms in various combinations may suggest ...

β-Thalassemia is a genetic disorder characterized by reduced or absent synthesis of the beta chains of hemoglobin, leading to ineffective erythropoiesis and severe anemia. Patients with ...

Saturation of TfR1 leads to the dissociation of Hfe and the binding of the alter to the TfR2, which in turn influences the binding of BMP6 to its receptors on the membrane. Increased liver iron ...

Hemochromatosis is a condition in which too much iron builds up in the body. When people inherit the condition via their genes, it can be heterozygous or homozygous. “Heterozygous” means the person ...

Patients with serum ferritin levels higher than 1000 μg/L show a 91% increased risk for any fracture, with a doubled risk for vertebral and humerus fractures compared with those without iron overload.

BMP, bone morphogenetic protein; BMPR, bone morphogenetic protein receptor; HAMP, hepcidin; HFE, hereditary hemochromatosis protein; HJV, hemojuvelin; Holo-Tf, holo ...