Granuloma formation within media. CD4 + T cells secrete IFN-γ and TNF-α which together are responsible for recruitment of macrophages. ... Giant cell arteritis (GCA) ...

A common medication already used for autoimmune diseases such as rheumatoid arthritis is effective for patients with giant ...

Upadacitinib 15 mg — but not 7.5 mg — alongside a glucocorticoid taper demonstrated superior efficacy to placebo with a ...

“While the phase 3 results of GCAptAIN did not replicate the positive outcomes observed in the phase 2 trial, we remain committed to continuing to drive scientific progress and deepening the ...

SHREVEPORT, La. - Giant cell arteritis, also known as temporal arteritis, is a less common condition where people get inflammation of the arteries that go to the head and neck.

Permanent, severe loss of vision is a feared complication; however, it is not the sole possible devastating outcome of giant cell arteritis. Myocardial infarction, ischemic stroke and limb gangrene ...

Causes of Giant Cell Arteritis (Temporal Arteritis):Giant Cell Arteritis is an autoimmune disorder where the immune system mistakenly attacks healthy blood vessels, leading to inflammation. While ...

Among patients included in the study population, crude annual incidence rates for biopsy-proven giant cell arteritis were 2.9 per 100,000 for black individuals and 4.2 per 100,000 for white ...

Giant cell arteritis (GCA), also known as temporal or cranial arteritis, is a disease caused by inflammation of medium- and large-sized arteries. 1,2 The aortic arch and its major branches (i.e ...

During the first 24 months after being diagnosed with biopsy-proven giant cell arteritis, patients had a mortality rate ratio of 1.17 (95% CI 1.01-1.36) compared with population controls, ...

Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are linked conditions that occur in the elderly. GCA is a vasculitis of large- and medium-sized vessels causing critical ischemia.