Professor Deng Hongkui's team from the Peking University School of Life Sciences has made the first successful differentiation of human pluripotent stem cells into fully endocrine-subtype-complete ...

Organoids—tiny, lab-grown 3D clusters of cells—are a useful tool for studying organ development, disease, and drug responses. These miniature organs-in-a-dish are powerful, but they’re not perfect: ...

Immunofluorescence image of the pancreatic islets of a 50-year-old-female without diabetes. This individual had 54% beta cells (GREEN), 9% delta cells (WHITE) and 37% alpha cells (RED). Diabetes is ...

Diabetes is the most common and serious chronic disease worldwide, characterized by insufficient insulin to maintain proper blood glucose levels. It affects more than 12% of Americans and is the ...

Our glycaemic balance is based on the ability of the pancreatic beta cells to detect glucose and secrete insulin to maintain our blood sugar levels. If these cells malfunction, the balance is broken, ...

Researchers at Karolinska Institutet and KTH Royal Institute of Technology have developed an improved method for creating insulin-producing cells from human stem cells. In a newly published study, the ...

When a mouthful of water goes down the “wrong pipe”—heading toward the lungs instead of the gut—it triggers uncontrollable coughing. That’s because the upper airway senses the water and quickly ...

KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape To our knowledge, to date, no survival benefit has been demonstrated. Appraisal of ...

(A) Representative H&E staining image of a mouse pancreas. The black arrow denotes the acinar cells and the white arrow denotes the islet. (B) Representative image of electron microscopy analysis of ...

Hormones coordinate different body functions by carrying messages through the bloodstream to target cells and tissues. Hormonal imbalances occur through inadequate or excess hormone synthesis, which ...