Across contemporary cardiovascular clinical trials, the estimates of expected event rates and effect sizes that investigators use to calculate sample sizes—and funding requirements—often come in ...

Advances in high-throughput biology and computer science are driving an exponential increase in the number of hypothesis tests in genomics and other scientific disciplines. Studies using current ...

We report a set of tools to estimate the number of susceptibility loci and the distribution of their effect sizes for a trait on the basis of discoveries from existing genome-wide association studies ...