England have suffered significant injury news ahead of the Six Nations with Jamie George set to miss their opening fixture against Ireland. Hooker George, who has been replaced by Maro Itoje as captain,

England have been struck by an injury crisis less than a fortnight before the Guinness Six Nations with vice-captain Jamie George heading a significant list of withdrawals from Steve Borthwick’s squad.

With a record of five wins in 12 games, Jamie George will not go down as one of England’s great captains. Few men in the professional era, however, have skippered England with more pride or sacrificed more to lead their country.

England hooker Jamie George ruled out of Six Nations opener against Ireland - The Saracens player suffered a hamstring injury on Sunday.

First-choice scrum-half Alex Mitchell, who missed the autumn Tests with a neck injury, could also miss the game with a knee problem he picked up against Munster on Friday

ENGLAND HAVE BEEN hit by the loss of vice-captain Jamie George for their Six Nations opener against Ireland on 1 February, with Alex Mitchell also a doubt for the Dublin showdown. Hooker George suffered a hamstring injury in Saracens’ Investec Champions Cup defeat by Saracens on Sunday and will miss the start of the tournament,

Jamie George, replaced as England captain by Maro Itoje last week, has been ruled out of their Six Nations opener against Ireland, with scrumhalf Alex Mitchell also a doubt after the squad was hit by a raft of injuries.

Hooker Jamie George will miss England's Six Nations opener against Ireland while scrum-half Alex Mitchell is a doubt with a knee problem.

Former England captain Jamie George is now a major injury doubt for the Six Nations after picking up a knock in Saracens’ shock 32-24 defeat to Castres last night. George was named England skipper ahead of last year’s Championship,